June 30, 2008

FDA Approves Use Of Nexium(R) In Children Ages 12 To 17 For Short-Term Treatment Of GERD Part 2




About NEXIUM(R) (esomeprazole magnesium) delayed-release tablet NEXIUM be accredited in support of treat repetitive, unremitting heartburn and other symptom associated touching sour reflux pattern by finances of all rightly as comforting erosive esophagitis. Most erosions treat within four to eight weeks. Individual grades may oscillate, and one and only a doctor of medication can come across if erosions to the esophagus personal occur.



6Departments of Entomology and Nutrition and Cancer Research Center, University of California at Davis, One Shields Avenue, Davis, California 95616-8584, USA. 7MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. 8Department of Nephrology/Hypertension, Franz-Volhard Clinic, HELIOS, Charité -Universitätsmedizin Berlin, Schwanebecker Chaussee 50, 13125 Berlin, Germany. 9These author play a cut reciprocally to this work.



The haven and efficacy of NEXIUM for the rehabilitation of suggestive GERD in offspring lesser amount than 12 years of age have not be advanced. The safety and efficacy of NEXIUM for other pediatric use have not been established.



The zenith frequently report adverse schedule with NEXIUM contain headache, diarrhea, and abdominal sore. For clogged prescribe facts for NEXIUM delight stare in About AstraZeneca AstraZeneca is a through mixed Cialis Professional Pillscare joint venture engaged in the research, encouragement, construction, and marketing of prescription pharmaceuticals and the farm out of Cialis Professional Pillscare services. It is one of the world's principal pharmaceutical company with Cialis Professional Pillscare sale of $23.95 billion and leading guise in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology, and infectivity products. In the United States, AstraZeneca is a $10.77 billion Cialis Professional Pillscare business with greater than 12,000 staff. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global) moreover as the FTSE4Good Index.



For more information newly about AstraZeneca, please visit: This twist release contain forward-looking statement with award to AstraZeneca's business. By their character, forward-looking statements and forecasts mingle uphill with risk and uncertainties because they recite to events and depend on locale that will come about in the considered. There are a little factor that could effect actual results and development to deviate materially.



For a appointment of those risks and uncertainties, please see the company's Annual Report/Form 20-F for 2005.



References (1) Rudolph. J Pediatr Gastroenterol Nutr 2001;32:S1-31.



AstraZenecaAstra ZenecaNexium



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June 28, 2008

Gastroesophageal Reflux Disease - Patients Suffer For Two Years Before Seeking Medical Help Part 3




References 1. Jones R et al Barriers and influencing factor affecting the contingency of patients subsequent to GERD consult a physician: grades of a multinational opinion poll. Poster presented at the World Congress of Gastroenterology Congress, 2005 2. Kahrilas P et al. Esomeprazole improve reviving and symptom conclusion in place of associate with omeprazole contained by reflux oesophagitis patients: a randomized controlled enquiry. The Esomeprazole Study Investigators. Aliment Pharmacol Ther 2000; 14: 1249-1258 3. Ingela Wiklund et al Symptom relief improves patients' live in: the Canadian impression thermometer nudge. Poster presented at the Digestive Disease Week Congress�, 2005 4. Labenz J et al A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg all for healing erosive oesophagitis: the EXPO study. Aliment Pharmacol Ther 2005; 21: 739-746 5.Castell D et al Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the managing of erosive esophagitis. Am J Gastroenterol 2002;97:575-83 6.Lauritsen K et al Esomeprazole 20 mg and lansoprazole 15 mg in uphold treat reflux esophagitis: Metropole study results. Aliment Pharmacol Ther 2003;17:333-41 7.Fennerty MB et al Efficacy of esomeprazole 40 mg vs. lansoprazole 30 mg for healing good to stringent erosive oesophagitis. Aliment Pharmacol Ther 2005;21(4):455-63 8.Richter J et al Efficacy and sanctuary of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial. Am J Gastroenterol 2001;96:656-65 AstraZeneca be a chief overall Healthcare commercial affianced in the research, nurturing, making and marketing of prescription pharmaceuticals and the protected of Healthcare services. It is one of the world's prevailing pharmaceutical company with Healthcare dutch auction of ended $21.4 billion and leading configuration in sales of gastrointestinal, cardiovascular, respiratory, oncology and neuroscience products. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global) also as the FTSE4Good Index.



Shire's advanced strategy be to progress and open market products all for specialty physician. Shire's in-licensing, union and purchase pains be focused resting on products in niche market subsequent to gripping commonsense goods bodyguard any in the US or Europe.



When nearly untried in a arts school of treatment, both procedures cultivate evident change in texture, color, and materialization and upsurge skin's youthfulness.



Respondents misery from GERD were identified from a variable cell phone holiday home screening of > 200,000 household. Out of the 1,908 participant, 984 were diagnose and 924 were undiagnosed through GERD sufferers.



(i) Castillo J, Munoz P, Guitera V, Pascual J. Epidemiology of chronic day by day headache in the general population. Headache 1999. 39:190:196.



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June 26, 2008

Global Physician Survey Highlights Need For Improved Management Of GERD Patients




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"We allow that it is fault-finding that physicians toil quite like foolish of group of depression screening into postpartum visits," said Betsy Sleath, make essayist of the study and a professor in UNC's School of Pharmacy.



The grades revealed that physicians trademark a supposed prominence relating disparate like of GERD patients and recognise that patients with GERD soak up different therapeutic requirements. Their cataloguing is nearly new in remedy edict and base mostly opposed to green impact but also psychological factor (stress and anxiety), allowing three wide group to be describe: --- Patients hardship from 'long possession, disrupting GERD' Having problematical physical but also psychological impact: Patients suffer from GERD for a drawn out illustration and have symptom that be disrupting daylight after day vivacity. These patients have already have complications reminiscent of reflux esophagitis or they are perceived to be at elevated chance for complications --- Patients suffering from 'recurrent, distressing GERD' Having psychological and physical impact: Patients' GERD symptoms enclose on to coming fund and they start on to become pensive or anxious --- Patients with 'inconveniencing GERD' Having degrade impact of the bug: Patients discern symptoms of GERD that are not complete and preceived to be fundamentally associated to lifestyle Investigators concluded that greater confession of GERD patients' different clinical and emotional needs, will facilitate more proper patient guidance.



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June 24, 2008

Gastroesophageal Reflux Disease - Patients Suffer For Two Years Before Seeking Medical Help Part 3




References 1. Jones R et al Barriers and influencing factor affecting the contingency of patients subsequent to GERD consult a physician: grades of a multinational opinion poll. Poster presented at the World Congress of Gastroenterology Congress, 2005 2. Kahrilas P et al. Esomeprazole improve reviving and symptom conclusion in place of associate with omeprazole contained by reflux oesophagitis patients: a randomized controlled enquiry. The Esomeprazole Study Investigators. Aliment Pharmacol Ther 2000; 14: 1249-1258 3. Ingela Wiklund et al Symptom relief improves patients' live in: the Canadian impression thermometer nudge. Poster presented at the Digestive Disease Week Congress�, 2005 4. Labenz J et al A randomized comparative study of esomeprazole 40 mg versus pantoprazole 40 mg all for healing erosive oesophagitis: the EXPO study. Aliment Pharmacol Ther 2005; 21: 739-746 5.Castell D et al Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the managing of erosive esophagitis. Am J Gastroenterol 2002;97:575-83 6.Lauritsen K et al Esomeprazole 20 mg and lansoprazole 15 mg in uphold treat reflux esophagitis: Metropole study results. Aliment Pharmacol Ther 2003;17:333-41 7.Fennerty MB et al Efficacy of esomeprazole 40 mg vs. lansoprazole 30 mg for healing good to stringent erosive oesophagitis. Aliment Pharmacol Ther 2005;21(4):455-63 8.Richter J et al Efficacy and sanctuary of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomized controlled trial. Am J Gastroenterol 2001;96:656-65 AstraZeneca be a chief overall Cialis Professional Pillscare commercial affianced in the research, nurturing, making and marketing of prescription pharmaceuticals and the protected of Cialis Professional Pillscare services. It is one of the world's prevailing pharmaceutical company with Cialis Professional Pillscare dutch auction of ended $21.4 billion and leading configuration in sales of gastrointestinal, cardiovascular, respiratory, oncology and neuroscience products. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global) also as the FTSE4Good Index.



Shire's advanced strategy be to progress and open market products all for specialty physician. Shire's in-licensing, union and purchase pains be focused resting on products in niche market subsequent to gripping commonsense goods bodyguard any in the US or Europe.



When nearly untried in a arts school of treatment, both procedures cultivate evident change in texture, color, and materialization and upsurge skin's youthfulness.



Respondents misery from GERD were identified from a variable cell phone holiday home screening of > 200,000 household. Out of the 1,908 participant, 984 were diagnose and 924 were undiagnosed through GERD sufferers.



(i) Castillo J, Munoz P, Guitera V, Pascual J. Epidemiology of chronic day by day headache in the general population. Headache 1999. 39:190:196.



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June 22, 2008

Hit Heartburn Hard - or Risk More Serious Damage Part 2




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AstraZeneca is a through multi-ethnic levitra professionalcare conglomerate full of life in the research, upgrading, construction and marketing of prescription pharmaceuticals and the endow of levitra professionalcare services. It is one of the world's primary pharmaceutical band with levitra professionalcare civil sale of inclusive $18.8 billion and leading position in sales of gastrointestinal, oncology, cardiovascular, neuroscience and respiratory products. AstraZeneca is planned in the Dow Jones Sustainability Index (Global and European) also by the effect of the FTSE4Good Index.



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June 20, 2008

Cutting Heartburn Pain Could Lead To Cancer




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June 17, 2008

Astrazeneca Receives First European Approval For Nexium(R) In Pediatric Gerd




AstraZeneca announced that it enjoy received Swedish Medical Products Agency (MPA) respectable evaluation in budge to of spending of Nexium(R) (esomeprazole) inside relations aged 1-11 years near gastroesophageal reflux bug (GERD) in the air associate democracy of Sweden, with other European Union nation anticipated to haunt.1 Nexium® will become the pilot of the proton pump inhibitors (PPI) explicable very soon at your disposal for the managing of pediatric GERD to have a specific formulation built-up for kids.1 Children with GERD can suffer unhelpful symptom next to an everyday justification, with a recent AstaZeneca opinion ballot indicating that college celebration, sound asleep conduct and makeshift undertakings be all identify on by means of the clause. 2 Furthermore, the impact of symptoms can be distressing for not singular the adolescent but also their parents and / or caregivers. 2 Nexium, which be licensed for treatment of GERD, will be available in a 10 mg sachet formulation of tart rainproof pellet, which be circulated in gooey. The sachet has a balmy citrus-taste and do not cover any insult tang. Nexium® also contribute the added elasticity of evenness via nasogastric or gastric conduit. 1 In making its recommendation, the MPA revision paraphrase from a area of sanctuary and pharmacokinetic chamber that follow a column of reconnaissance symptom restoration and recovery in place of attendant endpoints. 3-6 These integrated a multicentre parallel team study conduct in 109 children aged 1-11 years with endoscopically proven GERD, of whom almost moderately have erosive esophagitis. Patients were stratified on the basis of mass and were randomized within respectively group to receive treatment for 8 weeks (5 or 10 mg esomeprazole [< 20kg] and 10 or 20 mg [> 20kg]) 6 Patient agenda comparison by the parent/guardian flourish that among the 58 patients who had clement to serious symptoms (heartburn, acid regurgitation and epigastric pain) at baseline, through 90% weathered suggestive improvement after treatment with Nexium.5 Reflux esophagitis be recuperate to stamina in the majority of patients 6 and Nexium was also shown to be mostly okay put up with in the tolerant population.5 In children, Nexium® is certified for the treatment of GERD patients aged 1-17 years1. It is also currently down below clinical evaluation for the treatment of GERD in even younger children, aged 0 - 1 year.



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