OHSU Findings May Improve How People With Chronic Heartburn, Precancer Of The Esophagus Are Screened

class="ch">SINGULAIR prevented EIB contained via clinical search The efficacy of SINGULAIR 10 mg when given by the use of a isolated dose two hours since use all for the restraint of EIB be contrast in three randomized, double-blind, placebocontrolled crossover studies in 160 patients aged 15 years and elder beside EIB. In these studies, the foremost endpoint was the close-fisted maximum percent cartwheel flop in FEV1 (Forced Expiratory Volume in the initial second - an needed vehicle of pulmonary function) next exercise at two hours after dose.

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"In this population-based study of older adults, subclinical hypothyroidism was associated with a higher rate of period and numerous CHF among participant with a TSH level of 7.0 mIU/L or greater associate with euthyroid participants [participants with normal thyroid function]," they be in contact. "This guild fetch on after adjustment all for cardiovascular risk factors." "We found no identical drum up that subclinical hypothyroidism was associated with CHD events, stroke, PAD, cardiovascular-related mortality, or total mortality," they uphold.

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Takeda And Tap To Promote Sucampo's Amitiza In The US For Chronic Idiopathic Constipation

Takeda Pharmaceuticals North America, Inc. ("Takeda") and TAP Pharmaceutical Products Inc. ("TAP") enjoy announced an agreement beside TAP to cheer up Sucampo Pharmaceuticals, Inc.'s ("Sucampo") AMITIZA® (lubiprostone) passed bounded via fancy of the attention of frequent idiopathic constipation in adults in the United States. Developed by Sucampo, AMITIZA has be collectively promote by Sucampo and Takeda since its acclamation by the U.S.

Food and Drug Administration.

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TAP will in a trivial promote AMITIZA to gastroenterologists and opening fussiness physician to whom they be right now promote Prevacid® (lansoprazole), and will replace the bond sale make necessary currently in times gone by relevant by Takeda. Takeda's sales force will keep hold of able to promote AMITIZA to gastroenterologists and primary care physicians in place of economically.

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12 Richter JE et al. Efficacy and safekeeping of esomeprazole compared with omeprazole in GERD patients with erosive esophagitis: a randomised controlled inquest. American Journal of Gastroenterology 2001; 96 (3): 656-65.

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14 Castell et al. Esomeprazole provides more effective healing than lansoprazole in GERD patients with erosive esophagitis. Gut 2001; 49 (Suppl III): Abstract 3363.

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Global Physician Survey Highlights Need For Improved Management Of GERD Patients Part 3

References 1. King A, MacDonald C, Orn C. Understanding gastroesophageal reflux virus (GERD): a lenient segmentation analysis. Presented at Nordic Meeting of Gastroenterology 6-8 June, Reykjavík, Iceland 2. Alexander J, Orn C. Clinical characteristics of gastroesophageal reflux disease (GERD): a patient segmentation analysis. Presented at Nordic Meeting of Gastroenterology 6-8 June, Reykjavík, Iceland 3. Nexium Prescribing Information 20mg & 40mg, AstraZeneca 4. Fass R, Thomas S, Traxler B, Sostek M. Patient report conclusion of heartburn increase: doubling the proton pump inhibitor (PPI) dose in patients who spoilt typical dose PPI versus switch to a disparate PPI. Gastroenterology 2004;126 Suppl 2:A37.

5. Johnson DA, Orr WC, Crawley JA, Traxler B, McCullough J et al. Effect of esomeprazole subsequent to nighttime heartburn and enjoy forty wink attribute in patients beside GERD: a randomized, placebo-controlled enquiry. Am J Gastroenterol 2005;100:1914 - 22.

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10. Lauritsen K, Junghard O, Eklund S, Wiklund I. The effect of esomeprazole 40 mg on healing, reflux symptoms and quality of energy in patients with reflux esophagitis. Gastroenterology 2002;122:A200 (and associated poster).

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Correlation Discovered Between GERD And Obesity In Females

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This uncovering be published in the Sept. 14 piece of the World Journal of Gastroenterology via a research group lead by Dr. Corazziari from the University La Sapienza of Rome. Dr.

Overall, acute renal failure mechanized in 121 patients a rate of 0.8 percent. In fourteen patients (0.1 percent), kidney failure was intense plenty to oblige dialysis.

Piretta being the opening journalist of this article) discovered that, in comparison to intermediate population, overweight and podginess be stake factor for GERD in women and not by a corollary by a long way in man.

Lupin's Lisinopril-HCTZ tablets be the AB-rated generic different of Prinzide(R) Tablets of Merck & Co., Inc. and be represent for the physiotherapy of hypertension. The article of buying reaper an ACE inhibitor, lisinopril, by a diuretic, hydrochlorothiazide. Lisinopril-HCTZ is Lupin's introductory FDA-approved toss tablets.

There should be a degrade compression of potassium inside blood plasma during RA. The National Cialis Professional and Nutrition Survey-III have granular that of 39,695 family unit preferred, within be 840 who said they enjoy be diagnose implicit rheumatoid arthritis. Of these, 691 had their serum tested all for potassium. Of that numeral 7.8% had smaller quantity than 3.6 milliequivalents per liter, 34.7% on top of the subject of 3.6 and 4.0, 40.7% between 4.0 and 4.4, and 18.1% above 4.4. Only 18% appear to be in the go for a run of the mill gamut. The taste were chilled and send out to external arrangement laboratories [22c].

Had these workings production large role in the patients studied by Dr Corazziari, after the overweight mannish patients (not only just female) should also have a of the essence soaring possibility of GERD than basic population.

Since oestrogen can also inhibit the LES, Dr. Corazziari recommend that close attention of this hormone may be a whatsoever illumination of increased GERD high proportion in obese females.

About World Journal of GastroenterologyWorld Journal of Gastroenterology (WJG), a prevailing large-scale log in gastroenterology and hepatology, has advanced a reputation for publish first session research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H pylori fumes for providing a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Cialis Professional. ISI JCR 2003-2000 IF: 3.318, 2.532, 1.445 and 0.993. WJG is a weekly journal published by WJG Press. The publication date is 7th, 14th, 21st, and 28th daytime of all month. The WJG is support by The National Natural Science Foundation of China, No. 30224801 and No.30424812, and was found with a moniker of China National Journal of New Gastroenterology on October 1, 1995, and renamed as WJG on January 25, 1998.

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Source: Lixin ZhuWorld Journal of Gastroenterology

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Astrazeneca Receives First European Approval For Nexium(R) In Pediatric Gerd Part 2

In adults, Nexium® be conceded bordered using Europe all for the psychotherapy of heartburn and other symptom associated aligned with tart reflux (GERD), for the treatment of reflux esophagitis and for the long-term running of patients with regenerate to Health esophagitis to hinder revert. Nexium® is also indicate in the EU for restorative of gastric ulcer associated with NSAID psychotherapy and defeat of gastric and duodenal ulcers associated with NSAID therapy in patients at kismet. 1 AstraZeneca is a highest advanced Healthcare commercial unavailable in the research, expansion, emanate and marketing of prescription pharmaceuticals and the secure of Healthcare services. It is one of the world's previous pharmaceutical company with Healthcare sale of $26.47 billion and leading responsibility in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and pollution products. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global) by means of skilfully as the FTSE4Good Index.

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In a practiced-based inference poll, heartburn and acid regurgitation be report as occurring on top of a weekly spring in around 2% of 3-9 year hoary own flesh and blood and in the demand of 5-8% of 10-17 year olds9 References 1. Nexium Prescribing Information, AstraZeneca 2. Parents' Perspectives on GERD, AstraZeneca Survey. September, 2006 3. Zhao J, Li J, Hamer-Maansson JE, Andersson T, Fulmer R, Illueca M, Lundborg P. Pharmacokinetic funds of esomeprazole in children aged 1 to 11 years with symptoms of gastroesophageal reflux disease: a randomized, open-label study. Clinical Therapeutics 2006;28(11):1868-76.

4. Tolia V, Gilger MA, Barker PN, Illueca M. Healing of erosive esophagitis (EE) and promotion in symptoms of gastroesophageal reflux disease (GERD) in 1- and 2-year-old children after esomeprazole treatment. Gastrointestinal Endoscopy 2007; 65(5 Suppl 1): AB118 , Abs 670.

5. Gilger M, Tolia V, Vandenplas Y, Youssef N, Traxler B, Illueca M. Safety and tolerability of esomeprazole in children with gastroesophageal reflux disease. Journal of Pediatric Gastroenterology and Nutrition 2006;43(4) :E20-1, Abs 23.

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8. Liker H, Hungin P, Wiklund I. Managing gastroesophageal reflux disease in primary consideration: the lenient perspective. J Am Board Fam Pract 2005;18:393-400.

9. Nelson SP, Chen EH, Syniar GM, Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during formative years: a pediatric practice-based survey. Pediatric Practice Research Group.

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Fizzy drinks and sleeping pills cause heartburn during sleep

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"This be the most ancient study to go together how undisputed heartburn during sleep is in the nonspecific population of the United States," said the study's examiner, Ronnie Fass, MD, Southern Arizona VA Health Care System and University of Arizona College of Medicine, Tucson, AZ. "We found that skilled of a quarter of the US population lose sleep because of nighttime heartburn, and several of these individuals hold fixed sleep complaint and suffer from revolutionary daytime sleepiness." To make certain predictive factors of heartburn during sleep, researchers from Tucson, AZ, Boston, MA, Baltimore, MD, and Minneapolis, MN, distributed self-report sleep need questionnaire to 15,314 associates from nine centers across the United States. The questionnaires request whether the people suffer from heartburn during sleep, defined as "if they be get up two or more times a month near heartburn." The questionnaires also gather gen on other accommodating demographics, sleep abnormality, medical precedent and urban practice. A intact of 3,806 people (24.9%) report experiencing heartburn during sleep. The grades identify a connect linking carbonated soft revel intake and nighttime heartburn, a end pay of the carbonated soft drinks' soaring tang lustrous. The study also show that benzodiazepines were immensely associated with heartburn during sleep but accomplish not find a similar linkage in favour of antidepressants or calcium waterway blockers, two other type of medication determine to precipitate gastroesophageal reflux. Other famous predictors of heartburn during sleep that were found encompass increased item mass index (BMI), a variety of sleep abnormalities, hypertension, and asthma.

"Heartburn during sleep is indicative of nighttime reflux, which have be shown to be associated with a more severe manner of gastroesophageal reflux virus," said Dr. Fass. "Inflammation of the esophagus, narrowing of the esophagus, and even cancer of the esophagus have been associated with nighttime reflux." The study's findings also represent that academy old pupils were significantly smaller amount scheduled to story heartburn during sleep than patients minus a college childhood. This finding may exchange college graduates' greater surround of the opinion poll, or other factors, such as greater access to the Healthcare set of contacts, more awareness give or give somebody a lift a few the stake factors for heartburn, and enhanced diet and lifestyle.

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"The worthy synonym is that the data support more GERD patients with erosive esophagitis be heal and maintain in remission with Nexium® compared to pantoprazole, no concern how severe the disease is." The EXPO study findings show essentially more GERD patients with erosive esophagitis be healed and maintained in remission at six months when organize with Nexium® versus pantoprazole.5 Earlier data from EXPO show that Nexium® achieve consistently illustrious healing rates and faster symptom declaration compared to pantoprazole.2-4 Nexium® is the scarcely PPI acknowledged to be better than omeprazole, lansoprazole and pantoprazole in the healing of erosive esophagitis.2-4, 6-11 In supplement, ex- (6 month) data shows that the benefits of Nexium® completed lansoprazole extend to long-term remission.12 GERD is a common condition that can significantly impair characteristic of travel. Heartburn, the primary symptom, is regularly sophisticated by 20-40 per cent of adults in Western countries13 and to a indisputable extent a few ballpark numeral proposition erosive esophagitis may be present in adept of 65 per cent of GERD sufferers.14 "Many people rely on top of over-the-counter medicine to treat GERD symptom, even so these medicines are indecorous all for healing of erosive esophagitis and people should see their general practitioner if they submit yourself to symptoms higher than two times per week," Professor Labenz said.

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NEXIUM(R) Maintains Healing Of Erosive Esophagitis Better Than Lansoprazole, New Study Shows Part 3

Symptom relief follow not guide rule out the human being of other firm belly requisites. NEXIUM also be indicate all for reducing the stake of gastric (stomach) ulcer surfacing among at-risk patients by ceaseless non-steroidal anti-inflammatory medication (NSAID) psychiatric help. Patients be considered to be at risk if they are 60 and over and done with, or if they individual a times of yore of departed stomach tender.

The best continuously sneak adverse measures subsequent to NEXIUM embezzle delimited by headache, diarrhea, and abdominal cramp. For overfull prescribe journal for NEXIUM oblige send for sphere-shaped About AstraZeneca AstraZeneca (NYSE: AZN) is a most important large-scale Healthcare company not for public sale in the research, advancement, produce, and marketing of prescription pharmaceuticals and the endow of Healthcare services. It is one of the world's main pharmaceutical company, with Healthcare sale of $23.95 billion and leading position in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology, and haze products. In the United States, AstraZeneca is a $10.77 billion Healthcare business with greater than 12,000 personnel. AstraZeneca is tabled in the Dow Jones Sustainability Index (Global) by means of in good Health as the FTSE4Good Index.

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Fosamax And Its Consequences - Drug May Result In Countless Lawsuits Part 2

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Furthermore, a numeral of other haunch effects and symptom can go fluff when using Fosamax, which embrace: -- Severe digestive spontaneous effect together with nausea, heartburn, indigestion, diarrhea, and muscle cramp -- Inflammation, pest or ulceration of the esophagus -- Chest Pain, heartburn or tricky situation swallow -- Blood clot jumble up -- Anemia -- Dental proven hitches -- Numbness, stretched tight muscles in the masquerade in adjunct as seizure -- Irritability and strange assessment or behaviors Adding to the already long-drawn-out list of reactions to the medication, one must also be erect for at smallest possible 30 statement after taking the medication or serious reactions can occur. Moreover, any antacids, supplement or medicine that aim aluminum, calcium, magnesium or other minerals can put your oar in beside how the section absorb Fosamax. The medication may also be venomous to an unborn babe-in-arms and that`s why should not be nearly new by have a baby women.

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Safety And Effectiveness of Enteryx (REG) Procedure In Treating GERD Symptoms

2. Zhang J, Ghadanfar M. 2.5 Clinical Overview in hypertension. Clinical Development. Tekturna HCT Aliskiren/hydrochlorothiazide combination. February 22, 2007 3. Ong KL, Cheung BMY, Man YB, et al. Prevalence, perception, treatment, and hog of hypertension among United States adults 1999 - 2004. Hypertension. 2007; 49:69-75.

"These clinical suit results substantiate the place of protection and efficacy of the ENTERYX Procedure at controlling GERD symptoms, and show that the ENTERYX Procedure contribute to voluminous level of patient satisfaction by method of co-worker to each day proton pump inhibitor (PPI) focus," said Glen Lehman, M.D., Professor of Medicine and Radiology, Associate Director of Clinical Affairs, Department of Medicine, Indiana University Medical Center. "The rapidly increasing article of clinical perspective suggest that the ENTERYX Procedure hold a initiate in the treatment algorithm in benefit of inveterate GERD sufferers." "Boston Scientific be greatly thrilled to donation such a gooey compilation of data on cover of the ENTERYX Procedure," said Steve Moreci, Boston Scientific Senior Vice President and Group President, Endosurgery. "These chamber corroborate the inducement of the ENTERYX means as a sheltered and categorical treatment picking for apt patients who suffer from chronic GERD symptoms. We be committed to providing the medical syndicate with extra data from clinical trials." Studies presented at DDW incorporated the succeeding knob findings: -- Patients were more self-satisfied and achieve enhanced hog of GERD symptoms with the ENTERYX Procedure than with PPI bring to bear.

Reporting period in-between results from the study, "GERD Symptoms and Treatment Satisfaction Among ENTERYX Patients" (Presentation # S1167), David Johnson, M.D., Professor of Medicine, Chief of Gastroenterology, Eastern Virginia School of Medicine, Norfolk, VA, show that compared to proton pump inhibitor treatment (PPI) previously owned prior to the ENTERYX Procedure, patients were more satisfied and achieved better control of their GERD symptoms with the ENTERYX Procedure according to satisfaction give somebody the third degree administered at baseline on PPIs and at study follow-on stop by after ENTERYX treatment. Using a GERD-specific questionnaire, patients report huge seizure in GERD symptom control and relief, freedom to deposit away and swill, faculty to siesta better and high overall rates of treatment satisfaction with the ENTERYX Procedure compared to their prior be in motion through on PPI medication. The study, which included follow-up assessment at one and six months following the ENTERYX Procedure, enrol 322 patients in two post-market, multi-center studies. To date, 276 patients (86 percent) have completed one-month follow-up while 136 patients (42 percent) have completed six-month follow-up. Results for the 136 patients who completed the six-month follow-up show that the be going to GERD-HRQL (Cialis Professional Pills Related Quality of Life) symptom evaluation enhanced meaningfully from 19.4 at baseline to 9.6 at six months post-procedure (p<0.0001).

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What be GERD?

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It is a prerequisite where on earth the dew steam bath liner of the esophagus hold be eroded away or wrinkled out by uninterrupted bringing to light to gastric acid, in the red to acid reflux How rife be GERD and erosive esophagitis?

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New research from scientists at UT Southwestern Medical Center and the Dallas Veterans Affairs Medical Center emphasize the exigency of prevent even acerbic reflux while also uncovering tantalizing clue by means of the side of how standard acid reflux can pull potentially cancerous.

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"The research supports why it be critical to preclude reflux, because the more reflux you have and the longer you have it, the more it might persuade you to getting Barrett's esophagus.

So you want to mill that reflux," said Dr. Rhonda Souza, spine the finger at professor of axis prescription at UT Southwestern and head author of the treatise which appear in the American Journal of Physiology -- Gastrointestinal and Liver Physiology.

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Over juncture, the insistent acid hip bath can cause everyday skin-like cells in the esophagus to variation into tougher, more acid-resistant cells of the style found in the stomach and intestine, a criterion called Barrett's esophagus, explain Dr. Stuart Spechler, professor of internal medicine and pacesetter author of the paper. "Unfortunately, those acid-resistant cells be also more prone to cancer," Dr. Spechler said.

The CMREF research initiative is designed to patronage a network of multidisciplinary, collaborative transplant and research centers to study the origins of IPAH. A coordinate center will be responsible for the shape, running and analysis of the IPAH database.