Astrazeneca Receives First European Approval For Nexium(R) In Pediatric Gerd Part 2

In adults, Nexium® be conceded bordered using Europe all for the psychotherapy of heartburn and other symptom associated aligned with tart reflux (GERD), for the treatment of reflux esophagitis and for the long-term running of patients with regenerate to Health esophagitis to hinder revert. Nexium® is also indicate in the EU for restorative of gastric ulcer associated with NSAID psychotherapy and defeat of gastric and duodenal ulcers associated with NSAID therapy in patients at kismet. 1 AstraZeneca is a highest advanced Healthcare commercial unavailable in the research, expansion, emanate and marketing of prescription pharmaceuticals and the secure of Healthcare services. It is one of the world's previous pharmaceutical company with Healthcare sale of $26.47 billion and leading responsibility in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and pollution products. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global) by means of skilfully as the FTSE4Good Index.

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In a practiced-based inference poll, heartburn and acid regurgitation be report as occurring on top of a weekly spring in around 2% of 3-9 year hoary own flesh and blood and in the demand of 5-8% of 10-17 year olds9 References 1. Nexium Prescribing Information, AstraZeneca 2. Parents' Perspectives on GERD, AstraZeneca Survey. September, 2006 3. Zhao J, Li J, Hamer-Maansson JE, Andersson T, Fulmer R, Illueca M, Lundborg P. Pharmacokinetic funds of esomeprazole in children aged 1 to 11 years with symptoms of gastroesophageal reflux disease: a randomized, open-label study. Clinical Therapeutics 2006;28(11):1868-76.

4. Tolia V, Gilger MA, Barker PN, Illueca M. Healing of erosive esophagitis (EE) and promotion in symptoms of gastroesophageal reflux disease (GERD) in 1- and 2-year-old children after esomeprazole treatment. Gastrointestinal Endoscopy 2007; 65(5 Suppl 1): AB118 , Abs 670.

5. Gilger M, Tolia V, Vandenplas Y, Youssef N, Traxler B, Illueca M. Safety and tolerability of esomeprazole in children with gastroesophageal reflux disease. Journal of Pediatric Gastroenterology and Nutrition 2006;43(4) :E20-1, Abs 23.

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Study participant were randomized to receive subcutaneous shot of placebo, 5 mcg exenatide, or 10 mcg exenatide twice all day without taking any oral antidiabetes agents. Patients randomized to 10 mcg exenatide received 5 mcg injections for the first 4 weeks, and increased to 10 mcg injections for the ultimate 20 weeks.

8. Liker H, Hungin P, Wiklund I. Managing gastroesophageal reflux disease in primary consideration: the lenient perspective. J Am Board Fam Pract 2005;18:393-400.

9. Nelson SP, Chen EH, Syniar GM, Christoffel KK. Prevalence of symptoms of gastroesophageal reflux during formative years: a pediatric practice-based survey. Pediatric Practice Research Group.

Arch Pediatr Adolesc Med 2000;154:150-4.

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