NEXIUM(R) Maintains Healing Of Erosive Esophagitis Better Than Lansoprazole, New Study Shows Part 2

"The rummage through show that esomeprazole (NEXIUM) be more grand than lansoprazole contained by association one of the important yardstick in like larger of clinical glory - maintain invigorating of erosive esophagitis," added Dr. DeVault. "Esomeprazole psychiatric therapy was competent to clout both mucosal smash alert and reflux symptom." Study Details The persecute was a randomized, double-blind, double-dummy, parallel-group study to equate the endoscopic and suggestive remission rates of NEXIUM beside those of lansoprazole in patients with heal position A-D erosive esophagitis. (Grades be bed by the side of the Los Angeles Classification System, which catalogue the harshness of esophageal inflammation. Grades A and B symbolize calm erosive esophagitis, and C and D be a simile of sober virus.) A prepared of 1,026 patients were randomized to once-daily therapy with any NEXIUM 20 mg (n=512) or lansoprazole 15 mg (n=514) for able to six months. Patients with grades C and D erosive esophagitis at baseline have be in the departed treat and healed (no endoscopic attestation of the disease) with either NEXIUM 40 mg or lansoprazole 30 mg once each day, while those with grades A and B erosive esophagitis had been gleefully treated with NEXIUM 40 mg. An upper endoscopy (an theory audition of the esophagus, tummy and upper aspect of the dumpy intestine) was perform at three and six months to establish the comparative remission rates of both physiotherapy group. Patients in both groups had no heartburn or run sour regurgitation symptoms during the week prior to respectively endoscopy. Both NEXIUM and lansoprazole were well-tolerated by the use of patients.

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The clique, chief by means of Tim Clayton and Tom Meade of the London School of Hygiene & Tropical Medicine's Medical Statistics Unit, carried out a clinical case-control study in a general practice database, the IMS Disease Analyzer Mediplus database (IMS), which is previously owned widely in epidemiological research. It contain list of some two million patients register near thereabouts 500 GPs.

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