The gel be call Carraguard and is made from carrageenan seaweed. The US Food and Drug Administration (FDA) own given it a "Generally Recognized As Safe" travel ahead in support of oral and topical employment.
Carraguard is the early stock designed to be a microbicide that have completed the dying period of clinical carrying out exam. The audition found it to be nontoxic for vaginal use, but it complete not extravaganza it be potent at stop the virus ratification from a man to a female during vaginal intercourse.
The randomized, clone unsighted, phase 3 trial puzzled 6,202 women and was carried out at three South African situation where on earth the HIV epidemic is acute. It started contained with March 2004 and the downfall in March 2007.
The women be inside society division into a Carraguard clique and a placebo group. Both group received a topical gel and condoms, and neither participant nor their doctors know who occupation the Carraguard and who got the placebo (double blind). All participants also received propaganda basically about HIV, counselling about safe sexual category and how to clement question of sexually show smoke, by system of okay as one medically scrutinize, and tested and treat for curable sexually transmitted infections.
The grades show 134 unmarked infections in the group that in the past personal Carraguard and 151 in the placebo group. This translate to an rate rate of 3.3 infections per 100 woman-years equate to 3.7, respectively, a flux that was not found to be statistically major.
The researchers found no refuge attached difference relating the placebo and the alive element group, and adverse whereabouts in the red to gel submission were slighter number important and special.
The researchers said this repercussion was inner because of what it means to the ladder forward of the subsequent classmates of microbicides, of which Carraguard is an important ingredient.
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Director of the Population Council's HIV and AIDS program, Naomi Rutenberg, said: "The Population Council will use these trial results to get faster the development of effective means for women to secure themselves fractious HIV." In the laboratory, Carraguard was found to be effective at stopping cell from invasion by HIV, and it also stopped mice getting greater than a few sexually transmitted infections. Carraguard and as good as products groundwork on carrageenan seaweed have be tested widely in trial in the US, Australia, Chile, the Dominican Republic, Finland, South Africa and Thailand, in complete 850 man and women.
The US Agency for International Development (USAID) and the Bill & Melinda Gates Foundation fund the trial. Speaking for USAID, their elevated science advisor, Jeff Spieler said they always knew it would filch a prolonged event to mask a elated microbicide: "The Population Council has done groundbreaking go over in completing this trial, even in nastiness of this we are dreadfully disappointed that the product was not shown to be effective," said Spieler.
"Now we all have got to redouble our rock-solid work to get it equally a microbicide that women can use to protect themselves," he urge.
Developing effective vaginal microbicides is important because it give women more opportunity for controlling the coat of HIV and other sexually transmitted infections, even more since widespread strategy are not always whatsoever.
Click here to cram more about microbicides from the Alliance for Microbicide Development.
Source: Population Council wring unchain.
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