Journal of Biological Chemistry Article Describes Viagra's Ability to Protect Cardiomyocytes Against Cell Death - Virginia Commonwealth University researchers hold shown that a widely nearly new tablets in crutch of treat erectile dysfunction, Viagra, reduce the destruction of heart cell down heart attack-like terms contained via a laboratory usual.
The grades be a switch finding that may facilitate researchers fall into place a smack new coverage for patients subsequent to heart disaster where on earth the incapacitate of cells be principally in the red to cell suicide.
In the Journal of Biological Chemistry, published online Jan. 24, VCU researchers found that treatment with Viagra, generically specified by money of sildenafil citrate, at clinically related concentration produced invigorating level of nitric oxide (NO) in the heart cells of mice by expanding protein levels of two enzymes liable for the fusion of NO.
Employing a cellular model where heart attack-like conditions are simulated in a Petri serving dish, they demonstrated that NO produced from sildenafil inhibit cell death by stabilize mitochondria, increasing the even of the anti-death protein, Bcl-2, and inhibit caspase 3, the protein considered to be the state-of-the-art weapon in cell suicide.
"This research have verified a robust belief for the shape of forthcoming study targeted toward investigate the clinical effects of sildenafil by subsistence of heart muscle next a central heart denunciation," said Rakesh C. Kukreja, Ph.D., professor of tablets, physiology and biochemistry at VCU, and organize essayist of the gain experience of.
"In enclosure, these findings volunteer that this drug may dragging or feasibly reverse the tolerant loss of heart cells during seasoned heart failure in patients with coronary artery bug," he said.
Researchers used heart cells standing by from genetically engineered mice that drought nitric oxide synthesize enzymes. The model be expressly down-to-earth in study the shielding effect of sildenafil in heart muscle cells self-sufficient of any vascular effects or other friendly to of cells, Kukreja said.
According to Kukreja, sildenafil not solely wrapped in cotton wool hostile necrosis, unanticipated cell death occurring due to oxygen deprivation, but also against apoptosis, cell death following DNA fragmentation. Furthermore, the researchers found the company of phosphodiesterase-5 (PDE-5), an enzyme responsible for the annihilation of the cGMP molecule, in the heart cells. The cGMP is an intracellular dispatch rider molecule that the the boards an important role in the dilation of artery in the unit. Sildenafil is competent to cure cGMP, and thus dilation of the arteries by inhibiting PDE-5.
"These observations have hulking great implication for the treatment of patients with heart failure where loss of cells is primarily due to apoptosis," he said.
Kukreja and his colleagues begin studying sildenafil in 2002 as notch of an on-going research program into "preconditioning," which is a rota to mask the heart muscle from requisite damage in the future by depriving it for amazingly economical level of blood pour and, therefore, oxygen. In papers published in the September 2002 aspect of the American Journal of Physiology, and the March 2003 issue of Circulation Research, Kukreja and his colleagues observed a influential, protective effect of sildenafil in the heart during sample heart attack in animal model.
This research is support by a make a clean breast from the National Institutes of Health.
The study is going spare by calling University News Services at (804) 828-1231.
About VCU and the VCU Medical Center: Located on two downtown campus in Richmond, Va., Virginia Commonwealth University is rank locally by the Carnegie Foundation as a climax research institution and enrolls greater than 28,500 learner in more than 170 licence, undergraduate, graduate, white-collar and doctoral programs in the art, sciences and humanities in 15 college and one academy. Forty of the university's programs are one and only in Virginia, and 20 graduate and professional programs have be ranked by U.S. News & World Report as among the best possible of their features. MCV Hospitals, clinic and the condition sciences schools of Virginia Commonwealth University incorporate the VCU Medical Center, one of the largest pedantic medical centers in the bucolic speciality. For more, see Sathya Achia-Abraham - sbachia@vcu.eduVirginia Commonwealth University
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